W. Alton Russell, PhD

Assistant Professor
Alton Russell

Alton joined the McGill School of Population and Global Health as an Assistant Professor in 2022. As a researcher, Alton has developed decision analytic models and data-driven analyses for multiple areas of health policy and clinical practice, including blood donation and transfusion, managing pediatric kidney disease, opioid use disorder and overdose, and gastroenterology. Alton is also:

You can view his CV here.


Interests
  • Data-driven decision analysis
  • Health policy modeling
  • Health technology assessment
Education
  • Postdoc, Mass General Hospital Institute for Technology Assessment, 2021

    Harvard Medical School

  • PhD, Management Science and Engineering, 2021

    Stanford University

  • MSc, Management Science and Engineering, 2018

    Stanford University

  • BSc, Industrial Engineering (Health Systems Engineering concentration), 2014

    North Carolina State University

  • BSc, Interdisciplinary Studies (Global Health and Sustainability concentration), 2014

    North Carolina State University


D3Mod Lab

The Data-Driven Decision Modeling Lab–or D3Mod Lab–aims to enable the efficient, effective, and equitable use of finite healthcare resources. We use do so by developing, assessing, and applying traditional decision modeling methods (mathematical modeling, simulation, optimization) together with data-driven methods (machine learning, Bayesian statistics). Our work informs challenging decisions in health policy and medicine. We are part of the McGill Clinical and Health Informatics Research Group and the McGill School of Population and Global Health in Montreal, Quebec, Canada.



Lab members

member

Yuan Yu
Postdoc

Small area estimation, Bayesian hierarchical modeling, Sampling methods, survey studies, Bayesian applications, statistical and machine learning

member

Jiacheng Chen
Research Associate

Public health data science, methods, infectious disease and nutritional epidemiology

member

Wanjin (Jennifer) Li
PhD student

Health technology assessment, Economic evaluation, Public health data science

member

Matthew Knight
MSc student

Clinical decision-making, Public health data science, Disease surveillance

member

Melina Thibault
PhD student

Health informatics/digital health, Health policy modeling, Non-communicable disease epidemiology

member

Nkasiobi Hossanna Nwobi
MSc student

Health policy modeling, Health surveillance, Impact evaluation

member

Sophie Cao
BSc student

Health policy modeling, Applied machine learning for health data, Human-computer interaction

member

Matthew Schinwald
PhD Rotation Student

Clinical decision modelling, Health policy modelling, Machine learning



Teaching

Alton teaches the following courses at McGill:

Research

The D3Mod lab’s research informs health policy and clinical decisions through data-driven modeling and analysis. We use methods from decision science, optimization, epidemiology, health economics, and machine learning to enable the efficient, effective, and equitable utilization of resources. We collaborate with stakeholders in medicine and health policy to maximize our impact on policy and practice while extending the state of the art in data-driven decision modeling.

A major area of focus is data-driven decision analytic modeling, which integrates individual-level data into models that compare health intervention or policy options. Traditionally, decision analyses either model an ‘average’ patient or a relatively homogeneous cohort of synthetic individuals, extracting values from the literature or expert opinion to characterize the impacted population and estimate the impact of policy alternatives. This assumes risks and costs are not distributed across the population and interventions' treatment effects are homogeneous. Our lab is developing methdos to directly integrate individual-level data to reflect the true heterogeneity in patient populations and capture differences in expected outcomes under different policy alternatives. This enables more accurate estimation of the trade-offs involved with an intervention and allows us to look at the distributional impact of interventions to reveal potential inequities.

Current projects

Currently funded projects include:

  • Analyzing the operational impact of a patient portal with propensity score matching

  • Assessing the public health value of blood donor data with Bayesian modeling

  • Developing an individualized approach to managing risk of iron deficiency in repeat blood donors using machine learning, optimization, and simulation

Prospective lab members

Current McGill students: if you are interested in working with the lab, please email me (Alton) your CV and a brief note about your interests. I can serve as the thesis supervisor for students in Epidemiology (MSc and PhD), Biostatistics (MSc and PhD), and Quantitative Life Sciences (PhD). For students in other degree programs, I may be able to serve as a practicum supervisor, co-supervisor, or committee member.

Prospective McGill students: For prospective PhD students in Epidemiology, Biostatistics, or Quantitative Life Sciences, please send me (Alton) your CV and a brief note about your interests, ideally two to three months before the application deadline. Feel free to reach out earlier if you would like to discuss applying for a specific fellowship or scholarship that is due before the PhD program application. For prospective or admitted MSc students in Epidemiology or Biostatistics, you are welcome to send your CV and a note about your interests. I typically meet with new MSc thesis students in their first semester and have them join the lab in the beginning of their second semester. In some cases, I am able to discuss potential projects and fellowship or studentship opportunities earlier. Developing a plan to apply for graduate funding (fellowships, studentships) can improve your probability of success.

Prospective postdoctoral researchers or research staff: If we have open research staff opportunities, these will be advertised on McGill’s Workday platform. Prospective postdoctoral researchers are welcome to reach out at any time, particularly if you have identified an external fellowship for which you’d like to co-develop an application.

Open science research philospohy

Our group works hard to produce research that is informative, rigorous, transparent, and reproducible. The Decision Modeling Lab Manual describes our approach to open research and dissemination.

Thank you to our funders

Research in the decision modeling lab is supported by grants from:

Major publications

(2022). Individualized risk trajectories for iron-related adverse outcomes in repeat blood donors. Transfusion.
(2021). Optimal portfolios of blood safety interventions: test, defer or modify?. Health Care Management Science.
(2021). Cost-effectiveness and budget impact of whole blood pathogen reduction in Ghana. Transfusion.
(2020). Baseline creatinine determination method impacts association between acute kidney injury and clinical outcomes. Pediatric Nephrology.
(2020). Clipping over the scope for recurrent peptic ulcer bleeding is cost-effective as compared to standard therapy: An initial assessment. Gastrointestinal Endoscopy Clinics of North America.
(2020). Active testing of groups at increased risk of acquiring SARS-CoV-2 in Canada: Costs and human resource needs. CMAJ.
(2019). Cost effectiveness of endoscopic resection vs transanal resection of complex benign rectal polyps. Clinical Gastroenterology and Hepatology.
(2019). Screening the blood supply for Zika virus in the 50 U.S. States and Puerto Rico: A cost-effectiveness analysis. Annals of Internal Medicine.

Former Members

memeber

Yangyuru (Catherine) Liu
Summer ‘22 BSc student

BS research project, 2022.
Next position: MSc Biostats McGill

member

Chen-Yang Su
’22 – ’23 PhD rotation student

PhD rotation student, 2022-23.

memeber

Huzbah Jagirdar
MSc student

Msc Epi, 2022-24.
Next position: Cytel clinical research