Information Systems-enabled Outreach Program for Adverse Drug Events: The ISTOP-ADE Trial
Medications are an effective intervention for managing and preventing health problems but their benefit can be undermined by non-adherence or adverse drug events (ADEs). As these issues are interconnected, efforts to improve non-adherence should also include reduction of ADEs. We have developed the ISTOP-ADE system (Information Systems-enabled Outreach for Preventing Adverse Drug Events) which enables timely monitoring of patients for ADEs and couples it with an intervention to manage ADEs. The objectives of this study are to determine whether the ISTOP-ADE system, compared to routine care, will reduce a) the probability of discontinuing of prognosis-altering medications, b) the probability of a patient experiencing a severe ADE, c) the proportion of patients experiencing ADEs, preventable ADEs, and ameliorable ADEs, and d) health services utilization.